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Liposomes (phospholipid nanoparticles)

Liposomes (phospholipid nanoparticles)

Fabrication using a microfluidic device
Highly stable liposomes
Increased penetration of active ingredients into the skin

Overview of Nippon Shokubai 's liposomes

This liposome "ILINPSOME" was born from a collaborative research project using Lilac Pharma's microfluidic device [iLiNP]. It is a stable hollow particle that has achieved higher concentration and simpler composition than conventional products, and has increased the freedom of formulation. It is possible to customize the particle size, etc.

Characteristics of Nippon Shokubai 's liposomes

High quality and high stability
No need to add thickeners, etc., and can be stored at room temperature for over a year
Approximately 200 trillion liposomes are present in 1 mL, demonstrating high permeability

Good storage stability (50℃, 1 month) of lotion formulation (1% liposome formulation)

ILINPSOME-V series (hollow type)

Cosmetic display name	Quasi-drug labeling name	Content (%)
water	purified water	73～94
Hydrogenated Lecithin	Hydrogenated soy phospholipids	5～15
BG	1,3-butylene glycol	1～20

Average particle size: 250nm or less
Simple composition: Does not contain xanthan gum (for stability) contained in other companies' liposomes

ILINPSOME-V-HC: 8% phospholipids
ILINPSOME-V-MC: 5% phospholipid, stable even in accelerated testing at 50℃ for 1 month, can be stored at room temperature

Approximately 200 trillion phospholipid nanoparticles are present in 1 mL of this product.

	pieces/mL	pieces/0.1mL (1 drop)
ILINPSOME-V-HC	210 trillion	21 trillion
ILINPSOME-V-MC	190 trillion	19 trillion

Measurement using NanoSight (Malvern Panalytical)

Permeability of Nippon Shokubai 's liposomes

Permeability evaluation

Liposomes made by iLiNP
・Remarkable penetration into the skin
・Suppresses transmission to the bottom
・Good stability

The amount of fluorescent dye in the initial sample was set to "100," and the amount of fluorescent dye after the penetration test was calculated as the "abundance ratio of each part to the initial sample."

	Made by iLiNP	Made by homomixer
time (hr)	1	4	1	4
Preparation	100	100	100	100
After the permeation test	upper skin	9	10	90	63
Inside the skin ^*	91	90	10	37
lower skin (permeate)	0.0000	0.0017	0.0322	0.2831
photograph
Appearance after 2 weeks